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Symptom

The client can not connect to the database throwing an exception similar to: 
[ioredis] Unhandled error event: Error: read ECONNRESET
    at TCP.onStreamRead (node:internal/stream_base_commons:211:20)

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Diagnosis

The server is TLS enabled but your connection (client) is not.

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Solution

Check your connection parameters and ensure you enable TLS. If you are using a Redis URL then it should start with rediss://. You can copy the correct client configuration from Upstash console clicking on Redis Connect button.